Exploratory analysis of single nucleotide polymorphism (SNP) for quantitative traits
Mario A. Cleves
UAMS College of Medicine, Department of Pediatrics
11219 Financial Centre Parkway, Suite 250, Little Rock, AR 72211
[email protected]
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Abstract. With the decreasing cost and the increasing ability to quickly genotype
single nucleotide polymorphisms (SNP) across the human genome, large
databases containing possibly hundreds of typed SNPs are becoming common in
population-based studies of quantitative traits. Testing for association
between individual SNPs and the quantitative trait is an important first
step in the discovery of disease susceptibility SNPs. This task, however,
could be time-consuming and tedious if a large number of SNPs is involved.
In this article, I introduce two new commands designed to facilitate the
screening and testing of multiple SNPs for possible association with
quantitative traits.
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Mario A. Cleves
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hwsnp, qtlsnp, genetic epidemiology, genetic linkage, QTL, biallelic marker, single nucleotide polymorphisms, Hardy–Weinberg
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